P-selectin on endothelial cells. EMEA0.3. Serinproteaser som sekreteras av mastceller är en viktig diagnostisk markör för typ 1 allergier (exempelvis anafylaxi;
Upon injury in a blood vessel, platelets become activated and adbere to prevent blood loss. Activated platelets express adhesion molecules on their surface that also make leukocytes adhere to the i
It binds to carbohydrates on neutrophils and monocytes. It is the primary ligand for the P-Selectin glycoprotein ligand-1 and is important in the initial recruitment of leukocytes and platelets during inflammation and injury. Recombinant Human P-Selectin Protein (Met1-Ala771) 13025-H02H with a fusion hFc Tag, is expressed in HEK293 Cells. With high purity, high biological activity, high stability, and other superior features, you can use this Human P-Selectin protein for relevant bioassay and related research. Upon injury in a blood vessel, platelets become activated and adbere to prevent blood loss. Activated platelets express adhesion molecules on their surface that also make leukocytes adhere to the i This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor Clq. Mangell, Peter et al. "Critical role of P-selectin-dependent leukocyte recruitment in endotoxin-induced intestinal barrier dysfunction in mice.".
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: Millipore. REACH Nr. : Denna produkt är en blandning. C1q induces a rapid up-regulation of P-selectin and modulates collagen-and collagen-related peptide-triggered activation in human platelets. C Skoglund, J HL-60 som rullar på substrat som P-och E-sel, såväl som på cellmonoskikt som uttrycker Beläggning av mikroflödeskanal med fibronektin eller P-/E-selectin. GBT is also advancing its pipeline program in SCD with inclacumab, a p-selectin inhibitor in development to address pain crises associated with the disease. Framför allt har arbetet fokuserats på proteinerna ICAM-1 och P-selectin som spelar en viktig roll för rekrytering av vita blodkroppar från blodet ut i vävnaden.
Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface. Gene expression databases. Bgee i: ENSG00000174175, Expressed in adrenal gland and 157 other tissues ExpressionAtlas i: P16109, baseline and differential: Genevisible i: P16109, HS: Organism-specific
P-selectin binder till P-selectin glycoprotein ligand 1 PSGL-1 på monocyten, andra leukocyter och endotel.Leder till adhesion av trombocyten till leukocyt och RCP9130, Prolactin, 1 mg. RCP9248, P-selectin (western blot control), 10 μg. RCP9249, P-selectin, 10 μg. RCP9250, P-selectin, 100 μg.
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189-194. Oct 17, 2000 Background—P-selectin mediates rolling of platelets and leukocytes on activated endothelial cells. After platelet activation, P-selectin is Abstract. P-selectin glycoprotein ligand 1 (PSGL-1, CD162) and integrin αMβ2 ( Mac-1, CD11bCD18) are leukocyte P-selectin is a transmembrane protein present in the α granules of platelets and the Weibel-Palade bodies of endothelial cells. Following activation, Mayadas et.al confirmed that the combination of P-selectin and its ligand PSGL-1 mediates the adhesion of platelets to vascular endothelial cells and promotes P-Selectin Antibody (AK4) is a monoclonal anti-CD62 antibody that detects human P-Selectin by WB, IP, IF and FCM. Cited in 9 publications. Nov 16, 2017 P-selectin (CD62), a member of the selectin family, is confined to the α-granules of platelets and Weibel-Palade bodies of endothelial cells. P-selectin belongs to the family of selectin adhesion molecules, and is expressed by platelets and endothelial cells on stimulation.
P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. P-selectin is partially responsible for the adhesion of certain leukocytes and platelets to the endothelium. Animal models have also shown the important role of P-selectin in the process of atherogenesis. P-Selectin, also known as CD62P, GMP-140, PADGEM, and LECAM-3, is a transmembrane adhesion protein that is upregulated on activated platelets and vascular endothelial cells. It binds to hematopoietic cell PSGL-1/CD162 with highly clustered O-linked sialyl Lewis-x (sLex ) tetrasaccharides and sulfated tyrosine, as well as to heparin sulfate,
P-selectin, the largest selectin, is stored in α-granules of platelets and in Weibel–Palade bodies of endothelial cells, and is translocated to the cell surface of activated endothelial cells and platelets.
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P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. P-selectin, the largest selectin, is stored in α-granules of platelets and in Weibel–Palade bodies of endothelial cells, and is translocated to the cell surface of activated endothelial cells and platelets. E-selectin is not expressed under baseline conditions, except in skin microvessels, but is rapidly induced by inflammatory cytokines.
1995 Sep 29;270(39):22677-80.
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P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets.
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It is known to play an important role in atherosclerosis.
Upon injury in a blood vessel, platelets become activated and adbere to prevent blood loss. Activated platelets express adhesion molecules on their surface that also make leukocytes adhere to the i
It is viewed as a key factor in thrombosis. P-selectin plasma from blood samples taken from the subjects of the study was analyzed and compared.
Inflammatoriska cytokiner inducerar det omedelbara sättet eller sättet för expression av P-selectin på endotelcellytor och P-selectin binder svagt of tumor nuclear factor-receptor 2 (TNF-R2), e-selectin, and endostatin were significantly lower after consumption of the RP diet compared with WP (p < 0.05). S Papyri , Select , in the hieratic character from the collections of the British Museum . Regnaud , P. , De primigenia vocis Kshatriyari atque de regiis insignibus P. 1. Inscriptiones Phoenicias continens. T. 1: 1–3 (text & pl.).